{"id":32077,"date":"2025-09-02T22:35:40","date_gmt":"2025-09-02T20:35:40","guid":{"rendered":"https:\/\/aceitescazorla.com\/benefits-of-evoo-an-ally-against-cancer\/"},"modified":"2025-09-02T22:35:41","modified_gmt":"2025-09-02T20:35:41","slug":"benefits-of-evoo-an-ally-against-cancer","status":"publish","type":"post","link":"https:\/\/aceitescazorla.com\/en\/benefits-of-evoo-an-ally-against-cancer\/","title":{"rendered":"Benefits of EVOO. An ally against cancer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"32077\" class=\"elementor elementor-32077 elementor-20744\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-30ab2dab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"30ab2dab\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c9cc9b8\" data-id=\"3c9cc9b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ac89cfe elementor-widget elementor-widget-text-editor\" data-id=\"3ac89cfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h1>The incidence of the consumption of Extra Virgin Olive Oil &#8220;EVOO&#8221; in the prevention against Cancer.<\/h1>\n<blockquote>Experimental carcinogenesis with 7,12-dimethylbenzanthracene (DMBA) and its inhibition with extra virgin olive oil and diet with ripe olives (Picual variety)\n\n<em>Authors: Juan J. Soto-Castillo and Isicio Ortega-Medina<\/em>\n\n<em>Department of Cytology and Normal and Pathological Histology, Faculty of Medicine, University of Seville, Seville, Spain.<\/em><\/blockquote>\n&nbsp;\n\nExtra virgin olive oil (EVOO) as an integral part of the Mediterranean diet plays a fundamental role in lipid oxidation, preventing the development of atherosclerosis.\n\nLow-density lipoprotein (LDL) is responsible for transporting cholesterol in the blood. The oxidation of lipids (LDL lipoprotein linked to cholesterol) favors the formation of atheroma plaques in the arteries, which causes hardening and obstruction of these blood vessels, leading mainly to a decrease in cardiac or cerebral blood supply. \n\nPolyphenols (substances that have one phenol group per molecule) are minor components of EVOO, they reduce lipid oxidation and protect against atherosclerosis, protecting low density lipoprotein (LDL) from oxidative damage. The Picual olive variety contains the most polyphenols. \n\nIn atherosclerosis, lipoprotein peroxidation occurs, which acts on macrophage and monocyte receptors with cholesterol deposition, causing an inflammatory reaction and proliferation of smooth muscle cells of the wall, leading to the formation of atheromas, which produce narrowing of the arterial lumen (see image below).\n\n<figure id=\"attachment_20746\" aria-describedby=\"caption-attachment-20746\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-20746 size-large\" src=\"https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-1024x682.jpg\" alt=\"\" width=\"1024\" height=\"682\" title=\"\" srcset=\"https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-1024x682.jpg 1024w, https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-300x200.jpg 300w, https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-768x512.jpg 768w, https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-1536x1024.jpg 1536w, https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-2048x1365.jpg 2048w, https:\/\/aceitescazorla.com\/wp-content\/uploads\/patogenesis-arterioscleriosis-1000x666.jpg 1000w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-20746\" class=\"wp-caption-text\">Pathogenesis of atherosclerosis. Robbins and Cotran. Structural and Functional Pathology (4)<\/figcaption><\/figure>\n\n&nbsp;\n\n&nbsp;\n\nTherefore, the benefits of EVOO are well known:\n<ul>\n \t<li>Reduced cardiovascular risk<\/li>\n \t<li>It reduces the oxidation of LDL-cholesterol (bad cholesterol) and increases HDL-cholesterol (good cholesterol) by acting as an antioxidant.<\/li>\n \t<li>Lowers blood pressure<\/li>\n \t<li>Decreases thrombosis and inflammation<\/li>\n \t<li>Protects against cognitive impairment<\/li>\n \t<li>Reduces the incidence of certain cancers.<\/li>\n<\/ul>\nIn this regard, it has been shown that the EVOO diet produces chemoprevention in experimental breast (2 and 5) and colon cancer (1). Likewise, EVOO has an inhibitory effect on experimental cancer induced by dimethylbenzanthrazene (DMBA) in the oral mucosa, esophagus and stomach in hamsters (6). Men\u00e9ndez et al. have shown that EVOO polyphenols inhibit erbB2 malignant transformation of human breast cancer epithelial cells. Owen et al. (3) express the importance of phenolic compounds isolated from olive oil as an antioxidant and their anticarcinogenic potential.     \n\n<a href=\"https:\/\/aceitescazorla.com\/wp-content\/uploads\/estudio-completo-DMBA.pdf\"><strong>You can read the full study here.<\/strong><\/a>\n\n<strong><a href=\"https:\/\/aceitescazorla.com\/wp-content\/uploads\/Salud-Aove-ingles.pdf\">Read this article<\/a><\/strong>\n\n<strong>Author<\/strong>: Dr. Isicio Ortega Medina. University Professor. University of Seville.  \n\n<strong>Bibliography<\/strong>\n<ol>\n \t<li>Bartoli R, Fern\u00e1ndez-Ba\u00f1ares F, Navarro E, Castell\u00e1 E, Ma\u00f1\u00e9 J, et al. Effect of olive oil on early and late events of colon carcinogenesis in rat: Modulations of arachidonic acid metabolism and local prostanglsndin E2 synthesis. Gut. 2000;46:191-9.   <\/li>\n \t<li>Men\u00e9ndez JA, V\u00e1zquez A, Oliveras C, Garc\u00eda R, Carrasco A, et al. Extra-virgin olive oil polyphenols inhibit HER2 (erbB2)-induced malignant transformation in human breast epithelial cells: Relationship between the chemical structures of extra-virgin olive oil secoiridoids and lingans and their inhibitory activities on the tyrosine kinase activity of HER2. Int J Oncol. 2008;34:43-51.   <\/li>\n \t<li>Owen RW, Giacosa A, Hull W, Haubner R, Spiegelhalder B et al. The antioxidant\/anticancer potential of phenolic compounds isolates from olive oil. Eur J Cancer. 2000;36:1235-47.   <\/li>\n \t<li>Robbins and Cotran. Structural and Functional Pathology. Kumar V, Ababas AK, Aster JC (Eds). Elsevier, Barcelona, 2015; pp.    497.<\/li>\n \t<li>Solanas M, Hurtado A, Costa I, Moral R, Men\u00e9ndez JA et al. Effect of a high olive oil diet on the clinical behavior and histopaphological features of rat DMBA-induced mammary tumors compared with an high corn oil diet. Int J Oncol. 2002;21:745-53.   <\/li>\n \t<li>Soto-Castillo JJ and Ortega-Medina I. Experimental carcinogenesis with 7,12 dimethylbenzanthracene (DMBA) and its inhibition with extra virgin olive oil and diet with ripe olives (Picual variety). Rev Esp Patol 2017;50(2):82-88. <\/li>\n<\/ol>\n&nbsp;\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The incidence of the consumption of Extra Virgin Olive Oil &#8220;EVOO&#8221; in the prevention against Cancer. Experimental carcinogenesis with 7,12-dimethylbenzanthracene (DMBA) and its inhibition with extra virgin olive oil and diet with ripe olives (Picual variety) Authors: Juan J. Soto-Castillo and Isicio Ortega-Medina Department of Cytology and Normal and Pathological Histology, Faculty of Medicine, University [&hellip;]<\/p>\n","protected":false},"author":4543,"featured_media":29174,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"on","ocean_gallery_id":[],"footnotes":""},"categories":[133],"tags":[139,140],"class_list":["post-32077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-aove-en","tag-greetings","entry","has-media","owp-thumbs-layout-horizontal","owp-btn-big","owp-tabs-layout-section","has-no-thumbnails","has-product-nav"],"_links":{"self":[{"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/posts\/32077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/users\/4543"}],"replies":[{"embeddable":true,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/comments?post=32077"}],"version-history":[{"count":2,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/posts\/32077\/revisions"}],"predecessor-version":[{"id":32081,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/posts\/32077\/revisions\/32081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/media\/29174"}],"wp:attachment":[{"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/media?parent=32077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/categories?post=32077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aceitescazorla.com\/en\/wp-json\/wp\/v2\/tags?post=32077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}